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High resolution platform developed to detect effect of prolonged alcohol exposure on RBCs

 

Scientists have custom-made a platform to detect the effect of prolonged alcohol exposure on Red Blood Cells (RBC) through high-resolution measurements of their size.

The high-resolution platform that shows the reduction in the size of RBCs on alcohol exposure can be tuned for a point-of-care screening of multiple conditions that alter the size and count of RBCs in the blood.

Although it is known that alcohol affects RBCs, the exact physiological changes are very subtle and difficult to measure. In order to overcome this challenge, scientists from Raman Research Institute (RRI), an autonomous institution funded by the Department of Science & Technology (DST), Government of India led by Professor Gautam Soni, have developed a custom-made electro-fluidic platform that can detect the change by measuring the cell size in enhanced resolution.

The device made in RRI relies on the resistive pulse sensing principle. The team first developed techniques for making tiny micron (1/1000th of a millimetre) sized holes or micro-pores at the tip of a glass capillary with careful fabrication, flame polishing, and image verification. Cells passing through the pore created very tiny electrical pulses, which give direct and most sensitive information of cell count and volume. These results may also be used to explain the lack of oxygen-carrying capability of RBC under alcohol exposure leading to blurred vision, muscular incoordination, and altered mental states from alcohol abuse. 

This research work, recently published in ACS Sensors journal of the American Chemical Societywas carried out by researchers Saurabh Kaushik, Manohara M., and K.D Murugan under the guidance of Dr Soni and Dr V. Sundaramurthy from National Centre for Biological Sciences (NCBS), Bangalore.

"Our lab had been working on building nanofluidic single-molecule detectors for the last few years. We found that some of the ideas used in the nanofluidic field may also be used in microfluidics in general and cell-biology in particular. We were pleasantly surprised with the reproducibility and resolution of our devices," said Professor Soni. Cell volume changes are an important biomarker for multiple diseases, especially blood-related conditions. Accurate measurement of volume changes of RBCs has applications in detection as well as mechanistic studies of diseases such as sickle cell anemia and malaria. Similarly, small volume changes of RBCs could also be indicators of malnutrition states in a cell. With this work, the RRI team envisages that the high-resolution platform can be tuned for a point-of-care screening of several other blood-related conditions.

#MinistryofScienceandTechnology
06-March-2021
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DRDO conducts successful flight test of SFDR

 

Defence Research and Development Organisation (DRDO) successfully carried out a flight demonstration based on Solid Fuel Ducted Ramjet (SFDR) technology from Integrated Test Range Chandipur off the coast of Odisha at around 10.30 am today.

All the subsystems, including the booster motor and nozzle-less motor, performed as expected. During the test, many new technologies were proven, including Solid Fuel based Ducted Ramjet technology, a release issued by the Ministry of Defence informed.

Successful demonstration of Solid Fuel based Ducted Ramjet technology has provided DRDO with a technological advantage that will enable it to develop long-range air-to-air missiles. Currently, such technology is available only in a handful of countries in the world. During the test, the air-launch scenario was simulated using a booster motor. Subsequently, the nozzle-less booster accelerated it to the required Mach number for Ramjet operation.

The performance of the missile was monitored using the data captured by Electro-Optical, Radar and Telemetry instruments deployed by ITR and confirmed successful demonstration of the mission objectives. The launch was monitored by senior scientists of various DRDO labs, including Defence Research & Development Laboratory (DRDL), Research Centre Imarat (RCI) and High Energy Materials Research Laboratory(HEMRL).

Defence Minister Rajnath Singh congratulated the scientists of DRDO, the Indian Air Force and the Industry on the successful flight test of SFDR.

#DRDO #Odisha
05-March-2021
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Amazonia 1 successfully separated from PSLV C51

 

Amazonia-1 satellite has been successfully separated from PSLV C-51 and placed into orbit today.

"In this mission, India and ISRO, feel extremely proud to launch the first satellite designed, integrated by Brazil. The satellite is in very good health. I congratulate the Brazilian team," ISRO Chairman K Sivan said about Amazonia-1 after the launch.

PSLV-C51/Amazonia-1 is the first dedicated commercial mission of NewSpace India Limited (NSIL), a Government of India company under the Department of Space. The NSIL is undertaking this mission under a commercial arrangement with Spaceflight Inc. USA.

#ISRO #PSLV
28-February-2021